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KMID : 0882420090760040402
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Korean Journal of Medicine
2009 Volume.76 No. 4 p.402 ~ p.408
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The clinical significance of new surrogate markers of hypertension
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Kim Kee-Sik
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Abstract
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Recently, the management of hypertension has focused on the prevention of target organ damage to organs such as the heart, kidney, brain, and blood vessels. To detect subclinical organ damage, several novel surrogate markers were established after amassing considerable evidence. Left ventricular hypertrophy, diastolic dysfunction measured by echocardiography, carotid intima-media thickness, ankle-brachial index, pulse wave velocity, central blood pressure, estimated glomerular filtration rate, and microalbuminuria have been proposed as new parameters to detect subclinical organ damage in patients with hypertension. The European guidelines for the management of arterial hypertension, published in 2007, suggested that risk stratification based on using new surrogate markers was important for classifying the stage of hypertension and choosing appropriate anti-hypertensive drugs. Therefore, these surrogate markers should be checked in the early phase of hypertension and their clinical importance considered in daily practice.
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KEYWORD
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Hypertension, Surrogate marker, LVH, Pulse wave velocity, Microalbuminuria
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